Lilemong tsa morao tjena, ho kenella le phello ea nanotechnology ho tsa bongaka, bioengineering le pharmacy e 'nile ea bonahala.Nanotechnology e na le molemo o ke keng oa nkeloa sebaka pharmacy, haholo-holo mafapheng a phepelo ea lithethefatsi e lebisitsoeng le ea lehae, phepelo ea lithethefatsi ea mucosal, kalafo ea liphatsa tsa lefutso le tokollo e laoloang ea protheine le polypeptide.

Lithethefatsi ka mefuta e tloaelehileng ea litekanyetso li ajoa ho pholletsa le 'mele ka mor'a ente ea intravenous, ea molomo kapa ea sebakeng seo,' me palo ea lithethefatsi tse hlileng li fihlang sebakeng sa sepheo sa phekolo ke karolo e nyenyane feela ea lethal dose, le ho ajoa ha lithethefatsi tse ngata libakeng tseo e seng tsa sepheo. ha e na phello ea phekolo feela, e tla boela e tlise litla-morao tse chefo.Ka hona, nts'etsopele ea mefuta e mecha ea litekanyetso tsa lithethefatsi e fetohile tataiso ea nts'etsopele ea litlhare tsa sejoale-joale, 'me lipatlisiso mabapi le sistimi e lebisitsoeng ea phepelo ea lithethefatsi (TDDS) e fetohile sebaka se chesang lipatlisisong tsa litlama.

Ha ho bapisoa le lithethefatsi tse bonolo, bajari ba lithethefatsi ba nano ba ka fumana phekolo e lebisitsoeng ea lithethefatsi.Phano ea lithethefatsi e reriloeng e bua ka mokhoa oa ho tsamaisa lithethefatsi o thusang bajari, li-ligands kapa li-antibodies ho khetha lithethefatsi sebakeng sa bona ho lebisa liseleng, litho tse lebisitsoeng, lisele tse shebiloeng kapa likarolo tsa intracellular ka tsamaiso ea lehae kapa tsamaiso ea mali.Tlas'a ts'ebetso ea mokhoa o khethehileng oa tataiso, nano ea tsamaisang lithethefatsi e fana ka moriana ho sepheo se itseng 'me o fana ka phello ea phekolo.E ka finyella sethethefatsi se sebetsang se nang le tekanyo e fokolang, litla-morao tse fokolang, phello e tsitsitseng ea lithethefatsi, bioavailability e phahameng, le ho boloka nako e telele ea phello ea mahloriso ho lipakane.

Litokisetso tse reriloeng ke haholo-holo litokisetso tsa bajari, tseo boholo ba tsona li sebelisang likaroloana tsa ultrafine, tse ka khethang ho bokella likaroloana tsena ka har'a sebete, spleen, lymph le likarolo tse ling ka lebaka la litlamorao tsa 'mele le fisioloji' meleng.TDDS e bua ka mofuta o mocha oa mokhoa oa ho tsamaisa lithethefatsi o ka tsepamisang maikutlo le ho beha lithethefatsi sebakeng sa lisele tse kulang, lithong, liseleng kapa ka har'a lisele tsa kahare ka phallo ea mali ea lehae kapa ea systemic.

Litokisetso tsa meriana ea Nano li lebisitsoe.Ba ka tsepamisa lithethefatsi sebakeng se lebisitsoeng ho se na tšusumetso e fokolang lithong tse sa lebelloang.Li ka ntlafatsa katleho ea lithethefatsi le ho fokotsa litla-morao tsa systemic.Li nkoa e le mefuta e nepahetseng ka ho fetisisa ea litekanyetso bakeng sa ho jara lithethefatsi tse thibelang mofetše.Hajoale, lihlahisoa tse ling tse reriloeng tsa ho itokisa li-nano li 'marakeng,' me palo e kholo ea litokisetso tsa nano li maemong a lipatlisiso, tse nang le menyetla e pharaletseng ea ts'ebeliso ea kalafo ea tumor.

Likarolo tsa litokisetso tse lebisitsoeng ho nano:

⊙ Ho lebisa tlhokomelo: sethethefatsi se tsepamisitsoe sebakeng se lebisitsoeng;

⊙ Fokotsa litekanyetso tsa meriana;

⊙ Ntlafatsa phello ea pholiso;

⊙ Fokotsa litla-morao tsa lithethefatsi. 

Phello e lebisitsoeng ea nano-itokisetso e lebisitsoeng e na le kamano e kholo le boholo ba likaroloana tsa ho itokisa.Li-particle tse nang le boholo bo ka tlaase ho 100nm li ka bokella mokong oa masapo;likaroloana tsa 100-200nm li ka ntlafatsoa libakeng tse tiileng tsa hlahala;ha 0.2-3um e kenngoa ke macrophages ka spleen;likaroloana> 7 μm hangata li ts'oaroa ke bethe ea pulmonary capillary ebe li kena liseleng tsa matšoafo kapa alveoli.Ka hona, litokisetso tse fapaneng tsa nano li bonts'a litlamorao tse fapaneng tsa sepheo ka lebaka la phapang ea boemo ba ho ba teng ha lithethefatsi, joalo ka boholo ba likaroloana le tefiso ea bokaholimo. 

Lits'oants'o tse sebelisoang hangata bakeng sa ho aha li-nano-platform tse kopaneng bakeng sa tlhahlobo le kalafo tse lebisitsoeng haholo li kenyelletsa:

(1) Lintho tse tsamaisang lipid, tse kang liposome nanoparticles;

(2) Li-polymer carriers, tse kang polymer dendrimers, micelles, polymer vesicles, block copolymers, protheine nano particles;

(3) Li-Inorganic carriers, tse kang nano silicon-based particles, carbon-based nanoparticles, magnetic nanoparticles, metal nanoparticles, le up-conversion nanomaterials, joalo-joalo.

Melao e latelang e lateloa ka kakaretso ha ho khethoa li-nano carriers:

(1) Sekhahla se phahameng sa ho jara lithethefatsi le litšobotsi tse laoloang tsa tokollo;

(2) Chefo e tlase ea likokoana-hloko 'me ha ho na karabelo ea 'mele ea ho itšireletsa mafung;

(3) E na le botsitso bo botle ba colloidal le botsitso ba 'mele;

(4) Tokisetso e bonolo, tlhahiso e bonolo ea tekanyo e kholo, le litšenyehelo tse tlaase 

Nano Gold Targeted Therapy

Khauta(Au) nanoparticlese na le ts'oaetso e ntle ea mahlaseli le lisebelisoa tsa optical, tse ka sebelisoang hantle ho radiotherapy e lebisitsoeng.Ka moralo o motle, likaroloana tsa khauta tsa nano li ka bokellana hantle ka har'a lisele tsa tumor.Li-nanoparticles tsa Au nanoparticles li ka ntlafatsa ts'ebetso ea mahlaseli sebakeng sena, hape li ka fetola matla a bobebe a ketsahalo hore e be mocheso ho bolaea lisele tsa mofetše sebakeng seo.Ka nako e ts'oanang, lithethefatsi tse holim'a likaroloana tsa nano Au li ka boela tsa lokolloa sebakeng seo, ho ntlafatsa phello ea phekolo. 

Li-nanoparticles li ka boela tsa lebisoa 'meleng.Li-nanopowder li lokisoa ka ho phuthela lithethefatsi le lintho tsa ferromagnetic, le ho sebelisa matla a khoheli a in vitro ho tataisa motsamao o lebisang le ho kenya lithethefatsi sebakeng sa 'mele.Lintho tse sebelisoang hangata, joalo ka Fe₂O₃, li ithutile ka ho kopanya mitoxantrone le dextran ebe e li phuthela ka Fe₂O₃ ho lokisetsa nanoparticles.Liteko tsa Pharmacokinetic li ile tsa etsoa ka litoeba.Liphetho li bonts'itse hore nanoparticles e lebisitsoeng ka matla a khoheli e ka fihla kapele mme ea lula sebakeng sa hlahala, bongata ba lithethefatsi tse lebisitsoeng ka matla sebakeng sa tumor bo phahame ho feta ba lisele tse tloaelehileng le mali.

Fe₃O₄e ipakile e se chefo ebile e lumellana le lintho tse phelang.E ipapisitse le thepa e ikhethang ea 'mele, ea lik'hemik'hale, ea mocheso le ea matla a khoheli, superparamagnetic iron oxide nanoparticles e na le monyetla o moholo oa ho sebelisoa libakeng tse fapaneng tsa biomedical, joalo ka ho ngolla lisele, sepheo le sesebelisoa sa lipatlisiso tsa tikoloho ea lisele, kalafo ea lisele joalo ka karohano ea lisele. le tlhoekiso;tokiso ea lisele;phano ea lithethefatsi;setšoantšo sa matla a khoheli a nyutlelie;kalafo ea hyperthermia ea lisele tsa mofetše, joalo-joalo.

Carbon nanotubes(CNTs)e na le sebopeho se sekoti se ikhethang le li-diameter tse ka hare le tse kantle, tse ka etsang bokhoni bo botle ba ho kenella ha lisele mme li ka sebelisoa e le li-nanocarriers tsa lithethefatsi.Ho feta moo, li-nanotubes tsa carbon li boetse li na le mosebetsi oa ho hlahloba lihlahala le ho phetha karolo e ntle ho tšoaea.Ka mohlala, carbon nanotubes e phetha karolo ea ho sireletsa litšoelesa tsa parathyroid nakong ea opereishene ea qoqotho.E ka boela ea sebelisoa e le letšoao la li-lymph nodes nakong ea opereishene, 'me e na le ts'ebetso ea litlhare tsa chemotherapy tse fokolang butle, tse fanang ka menyetla e pharaletseng ea thibelo le kalafo ea metastasis ea mofetše oa colorectal.

Ho akaretsa, ts'ebeliso ea nanotechnology mafapheng a bongaka le pharmacy e na le tebello e khanyang, 'me ka sebele e tla baka phetoho e ncha ea thekenoloji lefapheng la bongaka le pharmacy, e le ho kenya letsoho ho ntlafatsa bophelo bo botle ba batho le boleng ba bophelo bo botle. bophelo.